Mathematical immunology: processes, models and data assimilation
نویسندگان
چکیده
The immune system is a complex multiscale multiphysical object. Understanding its functioning in the frame of systemic analysis implies use mathematical modelling, formulation data consistency criterion, estimation parameters, uncertainty analysis, and optimal model selection. In this work, we present some promising approaches to modelling multi-physics processes, i.e., cell migration lymph nodes (LN), flow, homeostatic regulation responses chronic infections.
 To describe spatial-temporal dynamics LN, propose lymphocyte migration, based on second Newtons law considering three kinds forces. empirical distributions lymphocytes motility characteristics were used for calibration using KolmogorovSmirnov metric.
 Prediction flow node requires costly computations, due diversity sizes, forms, inner structure LNs boundary conditions. We proposed an approach replacing full-fledged computational physics-based with artificial neural network (ANN), trained set pre-formed results computed initial mechanistic model. ANN-based reduces time by four orders magnitude.
 Calibration MarchukPetrov antiviral response SARS-CoV-2 infection was performed. end, previously published viral load kinetics nasopharynx volunteers, observed ranges interferon, antibodies CTLs blood. which have most significant impact at different stages process, identified.
 Inhibition mechanisms, e.g., T exhaustion, distinctive feature infections malignant diseases. studies parameters exhausted subsets order examine balance their proliferation differentiation determined interaction SIRPa+ PD-L1+ XCR+1 dendritic cells. are evaluated, study reinvigoration effect aPD-L1 therapy homeostasis
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ژورنال
عنوان ژورنال: Russian journal of immunology : RJI : official journal of Russian Society of Immunology
سال: 2023
ISSN: ['1028-7221']
DOI: https://doi.org/10.46235/1028-7221-1210-mip